Manifestasi Neurologi Dari Gangguan Alergi

wp-1559363691580..jpgNeurologic Manifestations of Allergic Disease

Alergi makanan dapat menyebabkan sakit kepala, asma, bersin, ruam kulit, sakit perut, mengompol, kelelahan, lekas marah, kabut otak dan gejala neurologis lainnya, luka dingin, refluks esofagus, sindrom iritasi usus, gatal, gatal-gatal, nyeri otot dan persendian, cairan dalam telinga, pembengkakan sinus, suara serak, iritasi vagina, dan bahkan jantung berdebar. Alergen makanan juga dapat menyebabkan atau memperparah gangguan neurologis dan ADHD serta Sindrom Allergic Tension Fatigue

Alergi sistem saraf menyebabkan beragam gangguan perilaku, termasuk sakit kepala, kejang-kejang, ketidakmampuan belajar, skizofrenia dan depresi. Beberapa mekanisme biologis telah ditetapkan oleh penelitian; yang lain masih harus dijelajahi. Diagnosis dan pengobatan yang efektif termasuk diet eliminasi, diikuti oleh rotasi diet dan menghindari zat-zat penyebab.

Meskipun banyak penulis telah mempertimbangkan kemungkinan interaksi langsung antara alergi makanan dan perubahan perilaku, bukti yang mendukung hipotesis ini sulit dipahami. Setelah pemberian provokasi ovalbumin oral (OVA), tikus alergi menghadirkan tingkat kecemasan yang lebih tinggi, peningkatan ekspresi Fos di area otak yang berhubungan dengan emosi, dan keengganan terhadap solusi yang mengandung OVA. Selain itu, pengobatan dengan antibodi anti-IgE atau induksi toleransi oral menghilangkan penolakan makanan dan ekspresi c-fos dalam sistem saraf pusat (SSP). Penelitian itu mengungkapkan keterkaitan  langsung antara fungsi otak dan alergi makanan, sehingga menciptakan dasar yang kuat untuk memahami etiologi gangguan psikologis pada pasien alergi.

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