100 Penyakit Autoimmune

July 23, 2021July 23, 2021 DOKTER INDONESIA ONLINE

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Penyakit autoimun adalah keadaan patologis yang timbul dari respons imun tubuh yang tidak normal terhadap zat dan jaringan yang biasanya ada dalam tubuh. Autoimunitas, di sisi lain, adalah adanya respon imun self-reactive (mis., Auto-antibody, self-reactive T-cells), dengan atau tanpa kerusakan atau patologi yang dihasilkan darinya. Ini mungkin terbatas pada organ tertentu (mis. Pada tiroiditis autoimun) atau melibatkan jaringan tertentu di tempat yang berbeda (mis. Penyakit Goodpasture yang dapat memengaruhi membran dasar di paru-paru dan ginjal).

Sejumlah besar penyakit autoimun diakui. Pemahaman utama tentang patofisiologi yang mendasari penyakit autoimun telah menjadi aplikasi pemindaian asosiasi genome yang telah mengidentifikasi tingkat berbagi genetik yang mencolok di antara penyakit autoimun.

Other Qualifiers
A	“Accepted” in prior version of this table
C	A comorbidity common among people with autoimmune disease, but with no evidence of being itself caused by autoimmunity
E	Disease is an autoimmune response triggered by a specific environmental factor
F	Disease is only caused by autoimmunity in only a fraction of those who suffer from it
I	Described as an autoinflammatory disease
L	Evidence to indicate autoimmunity is extremely limited or circumstantial
M	Disease appears under Autoimmune Diseases in MeSH
N	Not listed in prior version of this table
R	Disease appeared in prior version but has been renamed. In renaming, precedence has been given to scientific names over those based on discoverers.
S	“Suspected” in the prior version of this table
T	Disease has a known trigger, such as viral infection, vaccination, or injury
X	An extremely rare disease, which would suggest limited opportunity to study it and conclusively determine whether it is caused by autoimmunity
Y	Listed in the prior version of this table with “Accepted/Suspected” left blank

Penyakit Auto Imun

Nama Organ	Penerimaan Autoimmunity	Hypersensitivitas (I,II,III,IV)	Autoantibodi / Sinonim / Varian Langka
Major Organs
JANTUNG
Myocarditis	Moderate, F, R, A		Sinonim: miokarditis autoimun, kardiomiopati autoimun, miokarditis Coxsackie
Postmyocardial infarction syndrome	Limited, R, Y		Autoantibodi: miokard neo-antigen terbentuk sebagai hasil dari MI. Sinonim: Sindrom Dressler
Postpericardiotomy syndrome	Limited, N
Subacute bacterial endocarditis^[	Limited, Y	III	Autoantibodi: cryoglobulinemia campuran esensial. Sinonim: SBE
GINJAL
Anti-Glomerular Basement Membrane nephritis	Moderate, R, M, A	II	Autoantibodi: Anti-Basement Collagen Tipe IV Protein. Sinonim: Sindrom Goodpasture, Glomerulonephritis Tipe 1
Interstitial cystitis	Limited, S		Mast cells.
Lupus nephritis	Comorbidity, N		A comorbidity of Systemic Lupus Erythematosis..
HATI
Autoimmune hepatitis	Moderate, A	cell-mediated	Autoantibodi: ANA dan SMA, LKM-1, LKM-2 atau LKM-3; antibodi terhadap antigen hati yang larut (anti-SLA, anti-LP) tidak terdeteksi autoantibodi (~ 20%) [rujukan?]. Sinonim: Lupoid hepatitis
Primary biliary cirrhosis	Moderate, A		Autoantibodi: Anti-p62, Anti-sp100, Anti-Mitochondrial (M2) Anti-Ro alias SSA. Perhatikan bahwa Sjogren’s diklasifikasikan di beberapa tempat (mis., MeSH) sebagai penyakit reumatoid, tetapi tidak ada bukti yang diterbitkan untuk mendukung klasifikasi itu.
Primary sclerosing cholangitis	Limited, Y		Possible overlap with primary biliary cirrhosis. Autoantibodies: HLA-DR52a.
PARU
Antisynthetase syndrome	Limited, Y
KULIT
Alopecia Areata	Moderate, A		Autoantibodies: T-cells. Synonyms: Alopecia areata – Patchy, Totalis, Universalis
Autoimmune Angioedema^[	Limited, F, N
Autoimmune progesterone dermatitis	Limited, X, A
Autoimmune urticarial	Comorbidity, A
Bullous pemphigoid	Moderate, Y		Autoantibodies: IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes.
Cicatricial pemphigoid	Limited, R, X, Y		precipitates C3. Autoantibodies: anti-BP-1, anti BP-2. Synonyms: Benign Mucosal Pemphigoid, Ocular cicatricial pemphigoid
Dermatitis herpetiformis	Moderate, C, Y		Autoantibodies: IgA Eosinophilia; anti-epidermal transglutaminase antibodies.
Discoid lupus erythematosus	Limited, Y	III	IL-2 and IFN-gamma.
Epidermolysis bullosa acquisita	Moderate, Y		COL7A1.
Erythema nodosum	Limited, F, Y
Gestational pemphigoid	Limited, R, Y		Autoantibodies: IgG and C3 misdirected antibodies intended to protect the placenta.
Hidradenitis suppurativa	Limited, C, S
Lichen planus	Limited, Y
Lichen sclerosus	Limited, C, Y
Linear IgA disease	Moderate, Y		Synonyms: LAD
Morphea	Limited, C, S
Pemphigus vulgaris	Moderate, M, A	II	Autoantibodies: Anti-Desmoglein 3 eosinophilia.
Pityriasis lichenoides et varioliformis acuta	Limited, C
Mucha-Habermann disease	Limited, C, Y		T-cells. Synonyms: Pityriasis lichenoides, varioliformis acuta
Psoriasis	Moderate, A	IV?	CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB.
Systemic scleroderma	Limited, R, S		COL1A2 and TGF-β1. Autoantibodies: anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodies. Synonyms: Diffuse cutaneous systemic sclerosis, Systemic sclerosis, Scleroderma
Vitiligo	Limited, C, S		NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6.
Glands
Endocrine
Adrenal Gland
Addison’s disease	Moderate, F, Y		Autoantibodies: 21 hydroxylase.
Multi-glandular
Autoimmune polyendocrine syndrome	Moderate, A	Unknown or multiple	Synonyms: Whitaker’s Syndrome, APECED, Addisons Disease, Polyglandular Autoimmune Syndrome 1, PGAS-1, APS Type 1
Autoimmune polyendocrine syndrome type 2	Moderate, A		DQ2, DQ8 and DRB1*0404. Autoantibodies: anti-21 hydroxylase, anti-17 hydroxylase. Synonyms: Schmidt syndrome, Polyglandular Autoimmune Syndrome 2, PGAS-2, APS Type 2
Autoimmune polyendocrine syndrome type 3	Moderate, A		Synonyms: Polyglandular Autoimmune Syndrome 3, PGAS-3, APS Type 3
Pankreas
Autoimmune pancreatitis	Moderate, A		Autoantibodies: ANA; anti-lactoferrin antibodiesanti-carbonic anhydrase antibodies; rheumatoid factor.
Diabetes mellitus type 1	Moderate, A	IV	HLA-DR3, HLA-DR4. Autoantibodies: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), and insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies.
KELENJAR TIROID
Autoimmune thyroiditis	Strong, A	IV	HLADR5, CTLA-4. Autoantibodies: antibodies against thyroid peroxidase and/or thyroglobulin. Synonyms: chronic lymphocytic thyroiditis, Hashimoto’s thyroiditis
Ord’s thyroiditis	Moderate, Y
Graves’ disease	Moderate, M, A	II	Autoantibodies: thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR).
EKSOKRIN
Organ Reproduktif
Autoimmune Oophoritis	Moderate, N
Endometriosis	Limited, S
Autoimmune orchitis	Limited, N
Kelenjar Saliva
Sjogren’s syndrome	Moderate, A		Autoantibodies: anti-Ro. Also, they are often present in Sjogren’s syndrome..
SALURAN CERNA
Autoimmune enteropathy	Moderate, X, Y
Celiac disease	Moderate, A,E	IV??	HLA-DQ8 and DQ2.5. Autoantibodies: Anti-tissue transglutaminase antibodies anti-endomysial IgA, anti-gliadin IgA.
Crohn’s disease	Moderate, Y	IV	Innate immunity; Th17; Th1; ATG16L1; CARD15;XBP1;.
Microscopic colitis	Limited, S
Ulcerative colitis	Limited, A	IV
Tissue<Top>
Blood<Top>
Antiphospholipid syndrome	Moderate, M, A		HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. Autoantibodies: anti-cardiolipin;anti pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti apoH; Annexin A5.
Aplastic anemia	Limited, F, Y
Autoimmune hemolytic anemia	Moderate, M, A	II	complement activation.
Autoimmune lymphoproliferative syndrome	Moderate, A		TNFRSF6; defective Fas-CD95 apoptosis. Synonyms: Canale-Smith Syndrome
Autoimmune neutropenia	Moderate, F, N
Autoimmune thrombocytopenic purpura	Moderate, M, R, A		Autoantibodies: anti gpIIb-IIIa or 1b-IX. Synonyms: Idiopathic Thrombocytopenic Purpura
Cold agglutinin disease	Moderate, M, A	II	idiopathic or secondary to leukemia or infection. Autoantibodies: IgM. Synonyms: Autoimmune hemolytic anemia?
Essential mixed cryoglobulinemia	Limited, C, Y
Evans syndrome	Moderate, Y		Synonyms: A synonym for a combination of hemolytic anemia and thrombocytopenic purpura
IgG4-related systemic disease	Limited, C, N
Paroxysmal nocturnal hemoglobinuria	Limited, F, S
Pernicious anemia^[46]	Moderate, A	II	Autoantibodies: anti-parietal cell antibody.
Pure red cell aplasia	Limited, Y
Thrombocytopenia^[47]^[48]	Limited, F, Y	II	Berbagai mekanisme. Autoantibodi: glikoprotein IIb-IIIa atau Ib-IX di ITP anti-ADAMTS13 di TTP. dan HUS anti-cardiolipin (antibodi anti-cardiolipin) dan β2 glikoprotein I pada sindrom Antiphospholipid anti-HPA-1a, anti-HPA-5b, dan lainnya di NAIT. Sinonim: Trombositopenia neonatal
Connective Tissue, Systemic, and multi-organ<Top>
Adiposis dolorosa^[49]	Limited, L, S		Lipoid tissue. Synonyms: Dercum’s disease
Adult-onset Still’s disease^[50]	Moderate, Y		macrophage migration inhibitory factor. Autoantibodies: ANA.
Ankylosing Spondylitis^[26]^[27]	Limited, S		CD8; HLA-B27.
CREST syndrome	Limited, Y		Autoantibodies: Anti-centromere antibodies Anti-nuclear antibodies.
Drug-induced lupus	Moderate, Y		Autoantibodies: Anti-histone antibodies.
Enthesitis-related arthritis^[51]^[52]^[53]^[54]	Limited, C, Y		MMP3, TRLR2, TLR4, ERAP1. Autoantibodies: .. Synonyms: A subtype of Juvenile Rheumatoid Arthritis
Eosinophilic fasciitis	Limited, F, A		Synonyms: Shulman’s syndrome
Felty syndrome^[55]	Strong, M, Y
Juvenile Arthritis^[50]	Strong, M, R, Y		Autoantibodies: inconsistent ANA Rheumatoid factor. Synonyms: Juvenile rheumatoid arthritis, Juvenile idiopathic arthritis
Lyme disease (Chronic)^[56]	Limited, L, T, N
Mixed connective tissue disease^[15]	Moderate, M, A		HLA-DR4. Autoantibodies: anti-nuclear antibody anti-U1-RNP.
Palindromic rheumatism^[57]	Limited, Y		Autoantibodies: anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA). Synonyms: Hench-Rosenberg syndrome
Parry Romberg syndrome	Limited, Y		Autoantibodies: ANA.
Parsonage-Turner syndrome	Limited, Y
Psoriatic arthritis^[58]	Moderate, C, A	IV?	HLA-B27.
Reactive arthritis	Limited, C, F, Y		Synonyms: Reiter’s syndrome
Relapsing polychondritis^[59]	Strong, A		Synonyms: atrophic polychondritis, systemic chondromalacia, chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, generalized chondromalacia, systemic chondromalacia
Retroperitoneal fibrosis	Limited, Y
Rheumatic fever^[60]^[61]	Moderate, T, A	II	Autoantibodies: streptococcal M protein cross reacts with human myosin.
Rheumatoid arthritis^[15]	Strong, M, A	III	HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15). Autoantibodies: Rheumatoid factor (anti-IgGFc), Anti-MCV, ACPAs(Vimentin).
Sarcoidosis^[62]^[63]^[64]	Limited, S	IV	BTNL2; HLA-B7-DR15; HLA DR3-DQ2.
Schnitzler syndrome	Limited, L, X, Y		IgM?.
Systemic Lupus Erythematosus^[15]^[21]^[22]^[23]^[31]^[65]	Strong, M, A	III	Autoantibodies: Anti-nuclear antibodies anti-Ro. Also, they are often present in Sjogren’s syndrome. Eosinophilia. Synonyms: Lupus
Undifferentiated connective tissue disease	Moderate, C, A		HLA-DR4. Autoantibodies: anti-nuclear antibody. Synonyms: Latent lupus, incomplete lupus
OTOT
Dermatomyositis	Moderate, F, X, A		B- and T-cell perivascular inflammatory infiltrate on muscle biopsy. Autoantibodies: histidine-tRNA anti-signal recognition peptide Anti-Mi-2 Anti-Jo1.. Synonyms: Juvenile dermatomyositis
Fibromyalgia	Limited, C, F, N
Inclusion body myositis	Limited, F, Y		Similar to polymyositis but does not respond to steroid therapy-activated T8 cells.
Myositis	Limited, F, Y
Myasthenia gravis^[15]	Strong, M, A	II	HA-B8 HLA-DR3 HLA-DR1. Autoantibodies: nicotinic acetylcholine receptor MuSK protein.
Neuromyotonia^[68]	Limited, F, S	II?	Autoantibodies: Voltage-gated potassium channels. Synonyms: Isaacs’ Syndrome
Paraneoplastic cerebellar degeneration^[69]^[70]^[71]	Limited, Y	IV? II?	Autoantibodies: anti-Yo (anti-cdr-2 in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor.
Polymyositis^[66]	Limited, F, A		Autoantibodies: IFN-gamma, IL-1, TNF-alpha.
SISTEM PERSARAFAN
Acute disseminated encephalomyelitis	Strong, M, T, A		Synonyms: ADEM, Perivenous encephalomyelitis, Acute hemorrhagic leukoencephalitis, AHL, AHLE, acute necrotizing encephalopathy (ANE), acute hemorrhagic encephalomyelitis (AHEM), acute necrotizing hemorrhagic leukoencephalitis (ANHLE), Weston-Hurst syndrome, Hurst’s disease
Acute motor axonal neuropathy	Limited, N
Anti-N-Methyl-D-Aspartate Receptor Encephalitis	Moderate, N		Synonyms: Anti-NMDA Encephalitis
Balo concentric sclerosis	Moderate, Y		Synonyms: Balo disease, Schilders disease
Bickerstaff’s encephalitis	Limited, Y		similar to Guillain-Barré syndrome. Autoantibodies: Anti-GQ1b 2/3 patients.
Chronic inflammatory demyelinating polyneuropathy	Moderate, C, Y		similar to Guillain–Barré syndrome. Autoantibodies: anti-ganglioside antibodies. Synonyms: Relapsing polyneuropathy (CRP), chronic inflammatory demyelinating polyradiculoneuropathy, Chronic inflammatory demyelinating polyneuritis
Guillain–Barré syndrom	Strong, M, A	IV	Autoantibodies: Anti-ganglioside, anti-GQ1b. Synonyms: Miller-Fisher syndrome, Landry’s paralysis
Hashimoto’s encephalopathy	Moderate, C, X, A	IV	Autoantibodies: alpha-enolase. Synonyms: Steroid-responsive encephalopathy associated with autoimmune thyroiditis, SREAT, Nonvasculitic autoimmune meningoencephalitis, NAIM, Encephalopathy Associated with Autoimmune Thyroid Disease, EAATD
Idiopathic inflammatory demyelinating diseases	Limited, F, Y		A set of different variants of multiple sclerosis.
Lambert-Eaton myasthenic syndrome	Strong, M, Y		HLA-DR3-B8. Autoantibodies: voltage-gated calcium channels; Q-type calcium channel, synaptogagmin, muscarinic acetylcholine receptor M1.
Multiple sclerosis, pattern II	Strong, M, A	IV	Autoantibodi terhadap saluran kalium telah dilaporkan menunjukkan pola demielinasi II. Kasus-kasus lain menghadirkan autoimunitas terhadap MOG dan Anoctamin-2. [ Tiga varian autoimun yang dilaporkan adalah milik MS pattern II. Juga melibatkan HLA-DR2, PECAM-1, protein dasar anti-myelin. Autoantibodi: Anti-Kir4.1, Anti-MOG, Anti-ANO2 (heterogen). Sinonim: Sklerosis multipel progresif primer, Sklerosis multipel yang kambuh, sklerosis diseminata, ensefalomielitis penyebaran
Oshtoran Syndrome	X		Heritable, abnormalities in the kynurenine and glutamate metabolism
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus	Limited, F, S	II?	antibodies against streptococcal infection serve as auto-antibodies. Synonyms: PANDAS
Progressive inflammatory neuropathy	Limited, X, S		similar to Guillain-Barré syndrome. Autoantibodies: Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1b.
Restless leg syndrome	Limited, C, S		Dapat terjadi pada sindrom Sjogren, penyakit seliaka, dan artritis reumatoid atau gangguan metabolisme zat besi.
Stiff person syndrome^[81]	Limited, S		GLRA1 (glycine receptor). Autoantibodies: glutamic acid decarboxylase (GAD).
Sydenham chorea	Limited, T, Y
Transverse myelitis	Limited, M, A
MATA
Autoimmune retinopathy^[82]	Limited, X, N
Autoimmune uveitis	Moderate, F, A		Autoantibodies: HLAB-27?.
Cogan syndrome	Limited, F, Y
Graves ophthalmopathy	Moderate, M, N
Intermediate uveitis	Limited, L, Y		Synonyms: Pars planitis, Peripheral Uveitis
Ligneous conjunctivitis	Limited, L, N
Mooren’s ulcer	Limited, L, N
Neuromyelitis optica^[83]^[84]	Limited, M, Y	II?	Autoantibodies: NMO-IgG aquaporin 4. Synonyms: Devic’s disease
Opsoclonus myoclonus syndrome^[85]	Limited, X, S	IV?	Lymphocyte recruitment to CSF.
Optic neuritis	Limited, C, Y
Scleritis	Limited, C, Y
Susac’s syndrome	Limited, C, Y		Synonyms: Retinocochleocerebral Vasculopathy
Sympathetic ophthalmia	Limited, I, Y		Autoantibodies: ocular antigens following trauma.
Tolosa-Hunt syndrome	Limited, I, X, Y
Ears<Top>
Autoimmune inner ear disease^[86]	Limited, A		Synonyms: AIED
Ménière’s disease^[87]	Limited, Y	III?	Autoantibodies: major peripheral myelin protein P0.
Vascular system<Top>
Anti-neutrophil cytoplasmic antibody-associated vasculitis^[88]	Strong, M, A		Autoantibodies: Anti-neutrophil cytoplasmic(cANCA). Synonyms: Wegener Granulomatosis, Granulomatosis with Polyangiitis
Behçet’s disease	Limited, I, X, A		vaskulitis sistemik yang dimediasi imun; hubungan ke HLA-B51 (HLA-B27); manifestasi yang sangat berbeda dengan bisul sebagai gejala umum. Sinonim: Morbus Adamandiades-Behçet. Varian Langka: Sindrom Hughes-Stovin
Churg-Strauss syndrome^[31]	Limited, I, X, Y		Autoantibodies: p-ANCA Eosinophilia.
Giant cell arteritis ^[15]	Limited, I, R, A	IV	Synonyms: Cranial arteritis, Temporal Arteritis
Henoch-Schonlein purpura	Limited, L, Y		Autoantibodies: immunoglobulin A (IgA) and complement component 3 (C3). Synonyms: anaphylactoid purpura, purpura rheumatica, Schönlein–Henoch purpura
Kawasaki’s disease	Moderate, S,E^[89]		ITPKC HLA-B51. Synonyms: Kawasaki syndrome, lymph node syndrome, mucocutaneous lymph node syndrome
Leukocytoclastic vasculitis	Limited, L, Y
Lupus vasculitis	Moderate, C, N		A comorbidity of Systemic Lupus Erythematosis.
Rheumatoid vasculitis	Moderate, C, N		A symptom of Lupus.
Microscopic polyangiitis	Limited, Y		Binds to neutrophils causing them to degranulate and damages endothelium. Autoantibodies: p-ANCA myeloperoxidase. Synonyms: microscopic polyarteritis,microscopic polyarteritis nodosa, MPA
Polyarteritis nodosa	Limited, L, Y		Synonyms: panarteritis nodosa, periarteritis nodosa, Kussmaul disease, Kussmaul-Maier disease
Polymyalgia rheumatica	Limited, L, Y
Urticarial vasculitis^[90]	Limited, X, Y	II?	Clinically may resemble type I hypersensitivity. Autoantibodies: anti C1q antibodies.
Vasculitis^[30]	Strong, I, M, F, A	III	Autoantibodies: sometimes ANCA.

Komorbitas autoimun

Daftar ini mencakup kondisi yang bukan penyakit tetapi tanda-tanda umum penyakit autoimun. Beberapa, seperti Sindrom Kelelahan Kronis, kontroversial. Kondisi ini termasuk di sini karena mereka sering terdaftar sebagai penyakit autoimun tetapi tidak boleh dimasukkan dalam daftar di atas sampai ada bukti yang lebih konsisten.

Nama Organ/ Penyakit	Tingkat Penerimaan untukAutoimmunity	Autoantibodies/Sinonims
Chronic fatigue syndrome	Comorbidity, N	Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Complex regional pain syndrome	Comorbidity, N	Gejala penyakit autoimun atau aktivitas autoimun, tetapi bukan penyakit atau penyebab penyakit. Sinonim: Amplified Musculoskeletal Pain Syndrome, Reflex Neurovascular Dystrophy, Reflex sympathetic dystrophy
Eosinophilic esophagitis	Comorbidity, N
Gastritis	Comorbidity, Y	Mungkin merupakan gejala penyakit autoimun, tetapi bukan penyakit atau penyebab penyakit. Autoantibodi: antibodi serum antiparietal dan anti-IF.
POEMS syndrome^[91]	Comorbidity, Y	Mungkin merupakan gejala penyakit autoimun, tetapi bukan penyakit atau penyebab penyakit. Autoantibodi: interleukin 1β, interleukin 6 dan TNFα. faktor pertumbuhan endotel vaskular (VEGF), mengingat ..
Raynaud’s phenomenon	Comorbidity, S	Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease.
Primary immunodeficiency^[92]	Comorbidity, N	The condition is inherited, but it is associated with several autoimmune diseases.
Pyoderma gangrenosum	Comorbidity, Y	Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease.

Bukan Autoimun

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Pada saat ini, tidak ada bukti yang cukup – langsung, tidak langsung, atau tidak langsung – untuk menunjukkan bahwa penyakit ini disebabkan oleh autoimunitas. Ketentuan ini termasuk di sini karena:

Penyakit ini tercantum dalam versi sebelumnya dari tabel ini
Penyakit ini termasuk dalam beberapa daftar penyakit autoimun yang banyak digunakan. Ini termasuk di sini untuk memastikan bahwa seseorang yang mengunjungi halaman ini tidak menyimpulkan bahwa penyakit itu tidak dipertimbangkan. Sebelum memindahkan suatu kondisi dari sini ke daftar penyakit autoimun, referensi harus disediakan di halaman Wikipedia untuk kondisi yang mengarah pada bukti autoimunitas.

Nama Organ	Tingkat Penerimaan Autoimmunity	Hypersensitivitas (I,II,III,IV)	Autoantibodies/Sinonims
Agammaglobulinemia	Not Autoimmune, Y		An immune system disorder but not an autoimmune disease.. Autoantibodies: IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A.
Amyloidosis	Not Autoimmune, N		No consistent evidence of association with autoimmunity.
Amyotrophic lateral sclerosis	Not Autoimmune, Y		No consistent evidence of association with autoimmunity. Autoantibodies: Amyotrophic lateral sclerosis (Also Lou Gehrig’s disease; Motor Neuron Disease).
Anti-tubular basement membrane nephritis	Not Autoimmune, N		No consistent evidence of association with autoimmunity.
Atopic allergy	Not Autoimmune, Y	I	A hypersensitivity.
Atopic dermatitis	Not Autoimmune, Y	I	A hypersensitivity.
Autoimmune peripheral neuropathy	Not Autoimmune, F, A		A class of diseases, some of which may be autoimmune. See specific diseases that are listed as autoimmune..
Blau syndrome	Not Autoimmune, Y		Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity.
Cancer	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Castleman’s disease	Not Autoimmune, Y		Gangguan sistem kekebalan tetapi bukan penyakit autoimun .. Autoantibodi: Ekspresi berlebihan IL-6.
Chagas disease	Not Autoimmune, S		No consistent evidence of association with autoimmunity.
Chronic obstructive pulmonary disease	Not Autoimmune, S		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Chronic recurrent multifocal osteomyelitis	Not Autoimmune, Y		LPIN2, D18S60. Synonyms: Majeed syndrome
Complement component 2 deficiency	Not Autoimmune, Y		Mungkin merupakan gejala penyakit autoimun, tetapi bukan penyakit.
Congenital heart block	Not Autoimmune, N		May be related to autoimmune activity in the mother.
Contact dermatitis	Not Autoimmune, Y	IV	A hypersensitivity.
Cushing’s syndrome	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Cutaneous leukocytoclastic angiitis	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas. Autoantibodi: neutrofil.
Dego’s disease	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Eczema^[96]^[97]^[98]	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas. Autoantibodi: LEKTI, SPINK5, filaggrin., Faktor neurotropik yang diturunkan dari otak (BDNF) dan Substansi P ..
Eosinophilic gastroenteritis	Not Autoimmune, Y		Possibly a hypersensitivity. Autoantibodies: IgE, IL-3, IL-5, GM-CSF, eotaxin.
Eosinophilic pneumonia	Not Autoimmune, F, Y		Kelas penyakit, beberapa di antaranya mungkin autoimun. Secara khusus, sindrom Churg-Strauss, subtipe pneumonia Eosinofilik, adalah autoimun.
Erythroblastosis fetalis	Not Autoimmune, Y	II	Mother’s immune system attacks fetus. An immune system disorder but not autoimmune. Autoantibodies: ABO, Rh, Kell antibodies.
Fibrodysplasia ossificans progressiva	Not Autoimmune, Y		Possibly an immune system disorder but not autoimmune. Autoantibodies: ACVR1 Lymphocytes express increased BMP4.
Gastrointestinal pemphigoid	Not Autoimmune, A		No consistent evidence of association with autoimmunity.
Hypogammaglobulinemia	Not Autoimmune, Y		An immune system disorder but not autoimmune. Autoantibodies: IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B.
Idiopathic giant-cell myocarditis	Not Autoimmune, N		Tidak ada bukti konsisten penyebab autoimun meskipun penyakit ini ditemukan komorbiditas dengan penyakit autoimun lainnya. Sinonim: Myocarditis sel raksasa
Idiopathic pulmonary fibrosis	Not Autoimmune, Y		Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.. Synonyms: Fibrosing alveolitis
IgA nephropathy	Not Autoimmune, Y	III?	Autoantibodi: IgA diproduksi dari sumsum daripada MALT. Sinonim: nephrits IgA, penyakit Berger, Synpharyngitic Glomerulonephritis. Gangguan sistem kekebalan tubuh tetapi bukan penyakit autoimun.
Immunoregulatory lipoproteins^[	Not Autoimmune, N		bukan penyakit
IPEX syndrome	Not Autoimmune, N		Mutasi genetik pada FOXP3 yang mengarah pada penyakit autoimun, tetapi tidak ada bukti yang konsisten bahwa itu adalah gangguan autoimun itu sendiri .. Sinonim: X-linked polyendocrinopathy, imunodefisiensi dan diare-syndrome (XLAAD)
Ligneous conjunctivitis	Not Autoimmune, N		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Majeed syndrome	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas. Autoantibodi: LPIN2.
Narcolepsy	Not Autoimmune, Y	II?	Tidak ada bukti terkait dengan autoimunitas. Penelitian tidak dapat direproduksi. Autoantibodi: hypocretin atau orexin, HLA-DQB1 * 0602.
Rasmussen’s encephalitis	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas. Autoantibodi: antibodi anti-NR2A.
Schizophrenia	Not Autoimmune, S		Tidak ada bukti yang konsisten terkait dengan autoimunitas.
Serum sickness	Not Autoimmune, Y	III	A hypersensitivity.
Spondyloarthropathy	Not Autoimmune, Y		No consistent evidence of association with autoimmunity. Autoantibodies: HLA-B27.
Sweet’s syndrome	Not Autoimmune, Y		Tidak ada bukti yang konsisten terkait dengan autoimunitas. Autoantibodi: GCSF.
Takayasu’s arteritis	Not Autoimmune, Y
Undifferentiated spondyloarthropathy	Not Autoimmune, Y		Lihat artritis terkait Enthesitis.